The invention discloses a detachable large mixing and stirring mechanism. The detachable large mixing and stirring mechanism comprises a base, wherein support seats are arranged at two ends of the base; a driving mechanism is arranged on each support seat, and a transmission and a transmission shaft are arranged on the driving mechanism; a mixing and stirring bin is arranged between the driving mechanisms at two ends of the base; transmission ports are formed in two ends of the mixing and stirring bin; transmission gear ports are formed in the mixing and stirring bin; gear holders are arrangedin the positions, corresponding to the transmission gear ports, of the base; transmission gears are arranged on the gear holders; rotation mechanisms are arranged at upper and lower ends of two sidesof the mixing and stirring bin; a rotation gear and a rotation shaft are arranged on each rotation mechanism; each mixing and stirring barrel is arranged between the rotation mechanisms at the upperand lower ends in the mixing and stirring bin; rotation grooves are formed in the mixing and stirring barrels. The detachable large mixing and stirring mechanism has the advantages that material mixing and stirring sufficiency, uniformity and quality are improved, a dead angle during material mixing and stirring is avoided, the material mixing and stirring efficiency is increased, and the mechanism has better safe application performance and meets actual use demands.