A guide-wire guide-type naso-intestinal tube comprises a tube body, wherein length scales are disposed on the outer wall, the front end is provided with an entrance and a tube plug, and the tail end is equipped with an exit; a guiding guide wire is disposed in the tube body, the guiding guide wire enters from the tube body entrance and goes through from the exit, and a guide wire handle is disposed at the entrance end; a metal supporting rod is disposed at the center of the guiding guide wire, the outer layer of the metal support rod is wrapped by a plastic layer, a metal wire is wound spirally outside the plastic layer, and the metal supporting rod is not disposed in the guiding guide wire which is 3 cm away from the exit end; and four holes are formed in the side wall of the tube body close to the exit. The tube provided by the invention is characterized in that the structural design is applied, and the tail end of the tube body is equipped with the exit, so that the head of the guiding guide wire can go through from the exit and enter a stomach antrum part; the metal supporting rod is not disposed in the guiding guide wire which is 3 cm away from the exit end, and the structure is soft, so that damage to a gastrointestinal tract caused by penetration of the naso-intestinal tube can be avoided; and the tube direction can be changed according to demands, and the tube body can be smoothly guided into duodena.