The invention relates to the technical field of bee milk products, in particular to a preparation method of a three-treasure tablet. The method includes the following steps of a, taking certain parts of bee milk, ginseng powder, paecilomyces bepiali chen and pollen by weight; b, fermenting the weighed parts of pollen and ginseng powder, and refrigerating and storing the product in a low-temperature environment for standby application after taking out the product; c, smashing the weighed parts of bee milk freeze-dried powder and paecilomyces bepiali chen into powder with granularity smaller than 20 meshes, fermenting the powder for 60-72 hours at a temperature of 45 DEG C to 55 DEG C after mixing the powder, refrigerating the product for 180-240 hours at a temperature of -15 DEG C to -10 DEG C, storing the product at a temperature of 5 DEG C to 10 DEG C for standby application after taking out the product; d, mixing, pressing and drying the material obtained in the step b and the material obtained in the step c, and obtaining the three-treasure tablet. The prepared three-treasure tablet prepared in this way has the advantages of being good in kidney disease treatment effect, convenient to take, good in taste and simple in preparation process.