The invention provides a system for optimizing information interaction relationships between networking simulation nodes of multiple simulators. The system comprises a network topological structure analyzing and optimizing computer and a network topological structure analyzing and optimizing program. The network topological structure analyzing and optimizing program runs on the network topological structure analyzing and optimizing computer; the network topological structure analyzing and optimizing program comprises a network information acquiring and analyzing module, a network model building module, a network topological structure analyzing module, a network topological structure optimizing module and a network visualizing module; the modules serially work to complete communication network analyzing, optimizing and generating work. The system has the advantages that communication networks with 'tree' structures are flattened by the system when the existing multiple simulators network, information interaction relationships between computers are sequentially created according to degrees of requirements on information timeliness, and the communication networks can be built when the multiple simulators network on the basis that the integral network performance of the communication networks is considered; the information interaction timeliness, synchronism and accuracy of the various simulation nodes can be guaranteed when the multiple simulators network, and accordingly the network communication efficiency and the engineering development efficiency can be improved.