The invention relates to a luggage space splitter plate and a knapsack with the luggage space splitter plate. The luggage space splitter plate is formed by a middle splitter plate body, an upper combination part and a lower combination part, and the upper combination part and the lower combination part are connected to the two sides of the middle splitter plate body respectively in a foldable manner; and each of an upper side combination face of the upper combination part and a lower side combination face of the lower combination part is provided with a hook and loop fastener used for being detachably connected with a lining of a luggage in a fixed manner. The knapsack comprises a knapsack body; the knapsack body is formed by a knapsack bottom support and a knapsack upper cover; the knapsack upper cover is made of transparent materials; a baffle is detachably attached to the inner side of the knapsack upper cover; a pattern plate is clamped between the baffle and the knapsack upper cover; and a stopping piece used for preventing the pattern plate and the baffle from sliding off is arranged on the knapsack upper cover. By means of the luggage space splitter plate, space can be freely and efficiently used, and the structure is simple and practical. Meanwhile, patterns of the knapsack can be freely changed; the functions are diversified; use is convenient; and the practical performance is better achieved.