The invention relates to a high-efficiency pesticide composition for killing agricultural pests. The high-efficiency pesticide composition is composed of the following components in parts by weight: 25 to 45 parts of sulfoxaflor, 25 to 65 parts of sulfur fluoride oxime ether, 20 to 40 parts of dinotefuran and 20 to 60 parts of spirotetramat. The high-efficiency pesticide composition has the advantages of high efficiency, low use level, and availability for delaying the pesticide resistance of the pests and the like, can effectively reduce environment pollution and pesticide residues, has an obvious effect on killing diamondback moth, beet armyworm, cotton bollworm, stem borer, mealybugs, homoptera piercing-sucking mouthpart pests mainly including planthoppers, aphids and the like, target pests comprising tea pests mainly including tea tussock moth, tea lesser leafhopper and tea geometrid, citrus pests mainly including Phyllocnistis citrella Stainton, and vegetable pests mainly including cabbage worm and the like, and can reduce the destruction to the environment at the same time.