The invention relates to a cosmetic with biological activity, which is prepared from natural products contained in plants, and in particular relates to skin cream. The skin cream mainly consists of albolene, monoglyceride, sodium lauryl sulfate, octadecanol, liquid paraffin, propylene glycol, allantoin, eucalyptus oil, Angelica Essential Oil, valerian, rosewood essence oil, frankincense essential oil and purified water. The skin cream has the safety of natural cosmetics and biological activity functions, can promote cell regeneration, balance grease secretion, clean the skin, disinfect, kill bacteria, avoid infection and moisturize the skin, can achieve the effects of calming down, soothing nerves, activating collaterals, resisting mosquito allergy and curing skin abrasion or burn, refers to a purely natural plant extract and does not have any side effect. Therefore, the skin has ideal wettability and optimal nutrition state, and the effects of nourishing the skin and beautifying are achieved.