The invention relates to an efficient insecticide composition for killing agricultural pests. The efficient insecticide composition comprises the following components in parts by weight: 20-40 parts of sulfoxaflor, 10-60 parts of cypermethrin, 30-60 parts of phoxim and 10-40 parts of spirotetramat. The efficient insecticide composition provided by the invention has the advantages of being obvious in synergistic effect, and capable of reducing the using amount of active ingredients, reducing the using cost, delaying the production of drug resistance to the pests and effectively reducing the environmental pollution and pesticide residues, has a significant killing effect against diamondback moths, beet armyworms, leaf miners, thrips, tobacco cutworms, bean-pod borers and homopteran pests with piercing-sucking mouthparts, which mainly comprise cotton plant bugs, aphids, mealworms, planthoppers, scale insects and other pests, and is suitable for comprehensive control on the pests.