The invention relates to a hydrophilic anti-pollution polyether sulfone hollow fiber ultrafiltration membrane and a preparation process thereof. The membrane is prepared from a polyether sulfone membrane casting liquid by using a nonsolvent phase separation method in a spinning mode, wherein the polyether sulfone membrane casting liquid comprises the following components by weight: a, an initial membrane casting liquid which comprises 10-30% of polyether sulfone resin, 40-60% of polar solvent and 5-20% of additive; b, aluminum silicon binary composite wrapping modified nanoscale titanium dioxide which accounts for 0.05-2% of the initial membrane casting liquid. The nano titanium dioxide which is subjected to surface modification is good in dispersity in the membrane casting liquid, agglomeration is not easy to happen, the prepared ultrafiltration membrane is high in water flux and high in pollution prevention performance, the operation pressure and the chemical washing frequency of the ultrafiltration membrane in an application condition are greatly reduced, and the membrane has a good application prospect.