The invention relates to the technical field of decoupage handicraft articles and discloses a fabrication process of an anti-wrinkling and damp-proof decoupage handicraft article. The fabrication process comprises the following process steps of (1) fabricating a metal-coated plastic film; (2) fabricating a composite base material layer; (3) pressing reinforcing ribs; (4) additionally arranging accessory decoration layers. The fabrication process has the advantages that the process is simple, and the operation is convenient; the limitations caused by traditional materials are overcome, the feasibility for creating scissor-cut contents is greatly improved, an overall product is relatively attractive, the anti-pressure ability of a three-dimensional design is improved, and the anti-wrinkling and damp-proof decoupage handicraft article can keep a preferable three-dimensional effect after being pressed; furthermore, carriers of the article have strong wrinkling resistance, cannot be influenced by dampness and insolation, can be cleaned and repeatedly used and are convenient to be daily cleaned by people, and the economization and environmental protection purposes are achieved.